The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system

The aim of the present study was to identify the signaling mechanism(s) responsible for the modulation of growth hormone secretagogue receptor type 1a (GHSR1a)-associated Akt activity. Ghrelin leads to the activation of Akt through the interplay of distinct signaling mechanisms: an early G(i/o) prot...

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Autors principals: Lodeiro, Maria, Alén, Begoña O., Mosteiro, Carlos S., Beiroa, Daniel, Nogueiras, Rubén, Theodoropoulou, Marily, Pardo, María, Gallego, Rosalía, Pazos, Yolanda, Casanueva, Felipe F., Camiña, Jesus P.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204078/
https://ncbi.nlm.nih.gov/pubmed/21900501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-04-0373
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