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Coupling of T161 and T14 phosphorylations protects cyclin B–CDK1 from premature activation
Mitosis is triggered by the abrupt dephosphorylation of inhibitory Y15 and T14 residues of cyclin B1–bound cyclin-dependent kinase (CDK)1 that is also phosphorylated at T161 in its activation loop. The sequence of events leading to the accumulation of fully phosphorylated cyclin B1–CDK1 complexes re...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The American Society for Cell Biology
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3204060/ https://ncbi.nlm.nih.gov/pubmed/21900495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-02-0136 |
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