Electron microscopic measurement of chain flexibility of poly(dG-dC).poly(dG-dC) modified by cis-diamminedichloroplatinum(II).

The antitumor drug cis-diamminedichloroplatinum (II) (cis-Pt) forms bidentate adducts with guanine residues of poly(dG-dC).poly(dG-dC). The secondary structure of the polymer is altered. In this work, high resolution pictures of naked molecules, obtained by dark field electron microscopy reveal DNA...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Revet, B, Malinge, J M, Delain, E, Le Bret, M, Leng, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1984
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320368/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6542206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/12.22.8349
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