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HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges
T30177 is a G-rich oligonucleotide with the sequence (GTGGTGGGTGGGTGGGT) which inhibits the HIV-1 integrase activity at nanomolar concentrations. Here we show that this DNA sequence forms in K(+) solution a dimeric G-quadruplex structure comprising a total of six G-tetrad layers through the stacking...
Wedi'i Gadw mewn:
| Prif Awduron: | , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Oxford University Press
2011
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3203613/ https://ncbi.nlm.nih.gov/pubmed/21771859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr540 |
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