Cultured myoblasts from patients affected by myotonic dystrophy type 2 exhibit senescence-related features: ultrastructural evidence

Myotonic dystrophy type 2 (DM2) is an autosomal dominant disorder caused by the expansion of the tetranucleotidic repeat (CCTG)n in the first intron of the Zinc Finger Protein-9 gene. In DM2 tissues, the expanded mutant transcripts accumulate in nuclear focal aggregates where splicing factors are se...

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Detaylı Bibliyografya
Asıl Yazarlar: Malatesta, M., Giagnacovo, M., Renna, L.V., Cardani, R., Meola, G., Pellicciari, C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: PAGEPress Publications 2011
Konular:
Original Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203470/
https://ncbi.nlm.nih.gov/pubmed/22073373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4081/ejh.2011.e26
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