Overexpression of a Minimal Domain of Calpastatin Suppresses IL-6 Production and Th17 Development via Reduced NF-κB and Increased STAT5 Signals

Calpain, a calcium-dependent cysteine protease, is reportedly involved in the pathophysiology of autoimmune diseases such as rheumatoid arthritis (RA). In addition, autoantibodies against calpastatin, a natural and specific inhibitor of calpain, are widely observed in RA. We previously reported that...

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Main Authors: Iguchi-Hashimoto, Mikiko, Usui, Takashi, Yoshifuji, Hajime, Shimizu, Masakazu, Kobayashi, Shio, Ito, Yoshinaga, Murakami, Kosaku, Shiomi, Aoi, Yukawa, Naoichiro, Kawabata, Daisuke, Nojima, Takaki, Ohmura, Koichiro, Fujii, Takao, Mimori, Tsuneyo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203168/
https://ncbi.nlm.nih.gov/pubmed/22046434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027020
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