A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients

BACKGROUND: The human leucine-rich, repeat-containing G protein-coupled receptor (LGR) 5, also called GPR49, is a marker of stem cells in adult intestinal epithelium, stomach and hair follicles. LGR5/GPR49 is overexpressed in tumors of the colon, ovary and liver and in basal cell carcinomas. Moreove...

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Main Authors: Rot, Swetlana, Taubert, Helge, Bache, Matthias, Greither, Thomas, Würl, Peter, Eckert, Alexander W, Schubert, Johannes, Vordermark, Dirk, Kappler, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203099/
https://ncbi.nlm.nih.gov/pubmed/21978106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-429
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