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Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes.
The cytotoxic effect of diphtheria toxin requires the entry of its enzymatic A fragment (Mr approximately 21,000) into the cytosol of sensitive cells. We show that the B45 fragment (Mr approximately 24,000) forms, in lipid bilayers, pores that are large enough (diameter greater than or equal to 18 A...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1981
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320306/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6272284/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.8.4950 |
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