Cooperative Activation of CCL5 Expression by TLR3 and Tumor Necrosis Factor-α or Interferon-γ through Nuclear Factor-κB or STAT-1 in Airway Epithelial Cells

BACKGROUND: CCL5/RANTES contributes to prolonged eosinophilic inflammation and asthma exacerbation after a viral infection. We studied the mechanism of CCL5 expression using viral product double-stranded RNA (dsRNA), a ligand of Toll-like receptor 3 (TLR3), and inflammatory cytokines in airway epith...

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Bibliographic Details
Main Authors: Homma, Tetsuya, Matsukura, Satoshi, Hirose, Takashi, Ohnishi, Tsukasa, Kimura, Teruaki, Kurokawa, Masatsugu, Ieki, Koushi, Odaka, Miho, Suzuki, Shintaro, Watanabe, Shin, Sato, Masayuki, Kawaguchi, Mio, Schleimer, Robert P., Adachi, Mitsuru
Format: Artigo
Language:Inglês
Published: S. Karger AG 2010
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202927/
https://ncbi.nlm.nih.gov/pubmed/20523058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000312120
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