Human Thrombomodulin Knockin Mice Reveal Differential Effects of Human Thrombomodulin on Thrombosis and Atherosclerosis

OBJECTIVE: We sought to develop a murine model to examine the antithrombotic and antiinflammatory functions of human thrombomodulin in vivo. METHODS AND RESULTS: Knockin mice that express human thrombomodulin from the murine thrombomodulin gene locus were generated. Compared with wild-type mice, hum...

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Main Authors: Raife, Thomas J., Dwyre, Denis M., Stevens, Jeff W., Erger, Rochelle A., Leo, Lorie, Wilson, Katina M., Fernández, Jose A., Wilder, Jennifer, Kim, Hyung-Suk, Griffin, John H., Maeda, Nobuyo, Lentz, Steven R.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202707/
https://ncbi.nlm.nih.gov/pubmed/21885846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.236828
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