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Plasma membrane microdomains regulate TACE-dependent TNFR1 shedding in human endothelial cells
Upon stimulation by histamine, human vascular endothelial cells (EC) shed a soluble form of tumour necrosis factor receptor 1 (sTNFR1) that binds up free TNF, dampening the inflammatory response. Shedding occurs through proteolytic cleavage of plasma membrane-expressed TNFR1 catalysed by TNF-α conve...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Publishing Ltd
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3202671/ https://ncbi.nlm.nih.gov/pubmed/21645239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2011.01353.x |
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