Opposite effects of HIF-1α and HIF-2α on the regulation of IL-8 expression in endothelial cells

Recently we have shown that hypoxia as well as overexpression of the stable form of hypoxia-inducible factor-1α (HIF-1α) diminished the expression of interleukin-8 (IL-8) by inhibition of the Nrf2 transcription factor in HMEC-1 cells. Because HIF isoforms may exert different effects, we aimed to exa...

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Bibliographic Details
Main Authors: Florczyk, Urszula, Czauderna, Szymon, Stachurska, Anna, Tertil, Magdalena, Nowak, Witold, Kozakowska, Magdalena, Poellinger, Lorenz, Jozkowicz, Alicja, Loboda, Agnieszka, Dulak, Jozef
Format: Artigo
Language:Inglês
Published: Elsevier Science 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202637/
https://ncbi.nlm.nih.gov/pubmed/21925595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.08.023
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