Sustained Small Interfering RNA Delivery by Mesoporous Silicon Particles

RNA interference (RNAi) is a powerful approach for silencing genes associated with a variety of pathologic conditions; however, in vivo RNAi delivery has remained a major challenge due to lack of safe, efficient, and sustained systemic delivery. Here, we report on a novel approach to overcome these...

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Hauptverfasser: Tanaka, Takemi, Mangala, Lingegowda S., Vivas-Mejia, Pablo E., Nieves-Alicea, René, Mann, Aman P., Mora, Edna, Han, Hee-Dong, Shahzad, Mian M.K., Liu, Xuewu, Bhavane, Rohan, Gu, Jianhua, Fakhoury, Jean R., Chiappini, Ciro, Lu, Chunhua, Matsuo, Koji, Godin, Biana, Stone, Rebecca L., Nick, Alpa M., Lopez-Berestein, Gabriel, Sood, Anil K., Ferrari, Mauro
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202607/
https://ncbi.nlm.nih.gov/pubmed/20430760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3931
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