Protective CD8 Memory T Cell Responses to Mouse Melanoma Are Generated in the Absence of CD4 T Cell Help

BACKGROUND: We have previously demonstrated that temporary depletion of CD4 T cells in mice with progressive B16 melanoma, followed by surgical tumor excision, induces protective memory CD8 T cell responses to melanoma/melanocyte antigens. We also showed that persistence of these CD8 T cells is supp...

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Bibliographic Details
Main Authors: Côté, Anik L., Byrne, Katelyn T., Steinberg, Shannon M., Zhang, Peisheng, Turk, Mary Jo
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202545/
https://ncbi.nlm.nih.gov/pubmed/22046294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026491
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