MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression

The oncoprotein meningioma 1 (MN1) is overexpressed in several subtypes of acute myeloid leukemia (AML) and overexpression was associated with a poor response to chemotherapy. MN1 is a cofactor of retinoic acid receptor/retinoic x receptor (RAR/RXR)-mediated transcription and this study identified g...

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Bibliographic Details
Main Authors: Meester-Smoor, Magda A., Janssen, Marjolein J.F.W., Grosveld, Gerard C., de Klein, Annelies, van IJcken, Wilfred F.J., Douben, Hannie, Zwarthoff, Ellen C.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Carcinogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202306/
https://ncbi.nlm.nih.gov/pubmed/18632758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn168
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