Low renal mineralocorticoid receptor expression at birth contributes to partial aldosterone resistance in neonates

The human neonatal period is characterized by renal immaturity with impaired capacity to regulate water and sodium homeostasis, resembling partial aldosterone resistance. Since aldosterone effects are mediated by the mineralocorticoid receptor (MR), we postulated that this hormonal unresponsiveness...

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Hauptverfasser: Martinerie, Laetitia, Viengchareun, Say, Delezoïde, Anne-Lise, Jaubert, Francis, Sinico, Martine, Prevot, Sophie, Boileau, Pascal, Meduri, Géri, Lombès, Marc
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Endocrine Society 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201843/
https://ncbi.nlm.nih.gov/pubmed/19477942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-1498
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