Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3

Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for angiogenesis-deficient mutants in the zebrafish. Embryos lacking r...

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Bibliographic Details
Main Authors: Gore, Aniket V., Swift, Matthew R., Cha, Young R., Lo, Brigid, McKinney, Mary C., Li, Wenling, Castranova, Daniel, Davis, Andrew, Mukouyama, Yoh-suke, Weinstein, Brant M.
Format: Artigo
Language:Inglês
Published: Company of Biologists 2011
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201658/
https://ncbi.nlm.nih.gov/pubmed/22007135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.068460
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