Modification of the loops in the ligand-binding site turns avidin into a steroid-binding protein

BACKGROUND: Engineered proteins, with non-immunoglobulin scaffolds, have become an important alternative to antibodies in many biotechnical and therapeutic applications. When compared to antibodies, tailored proteins may provide advantageous properties such as a smaller size or a more stable structu...

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Autores principales: Riihimäki, Tiina A, Hiltunen, Soili, Rangl, Martina, Nordlund, Henri R, Määttä, Juha AE, Ebner, Andreas, Hinterdorfer, Peter, Kulomaa, Markku S, Takkinen, Kristiina, Hytönen, Vesa P
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201017/
https://ncbi.nlm.nih.gov/pubmed/21658230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-11-64
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