Topical Prolyl Hydroxylase Domain-2 Silencing Improves Diabetic Murine Wound Closure

BACKGROUND: Prolyl hydroxylase domain 2 (PHD2) has been implicated in several pathways of cell signaling, most notably in its regulation of hypoxia inducible factor (HIF)-1α stability. In normoxia, PHD2 hydroxylates proline residues on HIF-1α, rendering it inactive. However in hypoxia, PHD2 is inact...

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Bibliografiske detaljer
Main Authors: Wetterau, Meredith, George, Finny, Weinstein, Andrew, Nguyen, Phuong D., Tutela, John Paul, Knobel, Denis, Cohen, Oriana, Warren, Stephen M., Saadeh, Pierre B.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3200292/
https://ncbi.nlm.nih.gov/pubmed/21627711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1524-475X.2011.00697.x
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