Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?

Astrocytes are fundamental for brain homeostasis and the progression and outcome of many neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model of AD (3xTg-AD) generalised hippocampal astroglia atrophy precedes a restricted and specific β-amyloid (Aβ) plaque-r...

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Detalhes bibliográficos
Main Authors: Olabarria, Markel, Noristani, Harun N, Verkhratsky, Alexei, Rodríguez, José J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199854/
https://ncbi.nlm.nih.gov/pubmed/21801442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-55
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