Selective killing of human malignant cell lines deficient in methylthioadenosine phosphorylase, a purine metabolic enzyme.

Seven out of 31 (23%) human malignant tumor cell lines had no detectable methylthioadenosine phosphorylase activity (less than 0.001 nmol/min per mg of protein), assayed with 5'-chloroadenosine as substrate. The enzyme-deficient cell lines were derived from five leukemias, one melanoma, and one brea...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Kamatani, N, Nelson-Rees, W A, Carson, D A
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1981
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319979/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6785752/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.2.1219
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