Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide

BACKGROUND: RC-101, a cationic peptide retrocyclin analog, has in vitro activity against HIV-1. Peptide drugs are commonly prone to conformational changes, oxidation and hydrolysis when exposed to excipients in a formulation or biological fluids in the body, this can affect product efficacy. We aime...

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Bibliografiske detaljer
Main Authors: Sassi, Alexandra B, Bunge, Katherine E, Hood, Brian L, Conrads, Thomas P, Cole, Alexander M, Gupta, Phalguni, Rohan, Lisa C
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199744/
https://ncbi.nlm.nih.gov/pubmed/21801426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-8-27
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