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Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide
BACKGROUND: RC-101, a cationic peptide retrocyclin analog, has in vitro activity against HIV-1. Peptide drugs are commonly prone to conformational changes, oxidation and hydrolysis when exposed to excipients in a formulation or biological fluids in the body, this can affect product efficacy. We aime...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3199744/ https://ncbi.nlm.nih.gov/pubmed/21801426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-8-27 |
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