Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects

ADAR2 catalyses the deamination of adenosine to inosine at the GluR2 Q/R site in the pre-mRNA encoding the critical subunit of AMPA receptors. Among ADAR2 substrates this is the vital one as editing at this position is indispensable for normal brain function. However, the regulation of ADAR2 post-tr...

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Detalhes bibliográficos
Main Authors: Marcucci, Roberto, Brindle, James, Paro, Simona, Casadio, Angela, Hempel, Sophie, Morrice, Nicholas, Bisso, Andrea, Keegan, Liam P, Del Sal, Giannino, O'Connell, Mary A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199391/
https://ncbi.nlm.nih.gov/pubmed/21847096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.303
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