Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical.

Eighty percent of the single-strand DNA breaks induced by gamma-irradiation were prevented by the hydroxyl radical (.OH) scavenger dimethyl sulfoxide (Me2SO); CH4 was generated in the process as a product of the interaction of .OH and Me2SO. In contrast, Me2SO completely blocked DNA nicking by an ir...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Repine, J E, Pfenninger, O W, Talmage, D W, Berger, E M, Pettijohn, D E
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1981
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319933/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6940118/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.2.1001
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