Attenuation of antigen-induced airway hyperresponsiveness and inflammation in CXCR3 knockout mice

BACKGROUND: CD8+ T cells participate in airway hyperresponsiveness (AHR) and allergic pulmonary inflammation that are characteristics of asthma. CXCL10 by binding to CXCR3 expressed preferentially on activated CD8+ T cells, attracts T cells homing to the lung. We studied the contribution and limitat...

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Detalhes bibliográficos
Main Authors: Lin, Yi, Yan, Haibo, Xiao, Yu, Piao, Hongmei, Xiang, Ruolan, Jiang, Lei, Chen, Huaxia, Huang, Kewu, Guo, Zijian, Zhou, Wexun, Lu, Bao, Gao, Jinming
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199245/
https://ncbi.nlm.nih.gov/pubmed/21939519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-12-123
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