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Cell-Specific, Activatable and Theranostic Prodrug for Dual Targeted Cancer Imaging and Therapy
Herein we describe the design and synthesis of a folate-doxorubicin conjugate with activatable fluorescence and activatable cytotoxicity. In this study we discovered that the cytotoxicity and fluorescence of doxorubicin are quenched (OFF) when covalently linked with folic acid. Most importantly, whe...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3198802/ https://ncbi.nlm.nih.gov/pubmed/21910482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja207463b |
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