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Targeted Deletion of Nrf2 Reduces Urethane-Induced Lung Tumor Development in Mice
Nrf2 is a key transcription factor that regulates cellular redox and defense responses. However, permanent Nrf2 activation in human lung carcinomas promotes pulmonary malignancy and chemoresistance. We tested the hypothesis that Nrf2 has cell survival properties and lack of Nrf2 suppresses chemicall...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3198791/ https://ncbi.nlm.nih.gov/pubmed/22039513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026590 |
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