Targeted Deletion of Nrf2 Reduces Urethane-Induced Lung Tumor Development in Mice

Nrf2 is a key transcription factor that regulates cellular redox and defense responses. However, permanent Nrf2 activation in human lung carcinomas promotes pulmonary malignancy and chemoresistance. We tested the hypothesis that Nrf2 has cell survival properties and lack of Nrf2 suppresses chemicall...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bauer, Alison K., Cho, Hye-Youn, Miller-DeGraff, Laura, Walker, Christopher, Helms, Katherine, Fostel, Jennifer, Yamamoto, Masayuki, Kleeberger, Steven R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2011
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198791/
https://ncbi.nlm.nih.gov/pubmed/22039513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026590
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