The Antinociceptive Effects of JWH-015 in Chronic Inflammatory Pain Are Produced by Nitric Oxide-cGMP-PKG-KATP Pathway Activation Mediated by Opioids

BACKGROUND: Cannabinoid 2 receptor (CB2R) agonists attenuate inflammatory pain but the precise mechanism implicated in these effects is not completely elucidated. We investigated if the peripheral nitric oxide-cGMP-protein kinase G (PKG)-ATP-sensitive K(+) (KATP) channels signaling pathway triggered...

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Hlavní autoři: Negrete, Roger, Hervera, Arnau, Leánez, Sergi, Martín-Campos, Jesús M., Pol, Olga
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198780/
https://ncbi.nlm.nih.gov/pubmed/22031841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026688
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