Secreted Osteopontin Is Highly Polymerized in Human Airways and Fragmented in Asthmatic Airway Secretions

BACKGROUND: Osteopontin (OPN) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family and a cytokine with diverse biologic roles. OPN undergoes extensive post-translational modifications, including polymerization and proteolytic fragmentation, which alters its biologi...

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Bibliografiske detaljer
Main Authors: Arjomandi, Mehrdad, Frelinger, Jessica, Donde, Aneesh, Wong, Hofer, Yellamilli, Amritha, Raymond, Wilfred
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198733/
https://ncbi.nlm.nih.gov/pubmed/22031818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025678
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