Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β

Platelet-derived growth factor (PDGF) has been implicated in the pathobiology of vascular remodeling. The multikinase inhibitor imatinib that targets PDGF receptor (PDGFR), c-kit and Abl kinases, shows therapeutic efficacy against experimental pulmonary hypertension (PH); however, the role of PDGFR-...

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Bibliographic Details
Main Authors: Dahal, Bhola K., Heuchel, Rainer, Pullamsetti, Soni Savai, Wilhelm, Jochen, Ghofrani, Hossein A., Weissmann, Norbert, Seeger, Werner, Grimminger, Friedrich, Schermuly, Ralph T.
Format: Artigo
Language:Inglês
Published: Medknow Publications 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198653/
https://ncbi.nlm.nih.gov/pubmed/22034611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/2045-8932.83448
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