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FLASH: fast length adjustment of short reads to improve genome assemblies

Motivation: Next-generation sequencing technologies generate very large numbers of short reads. Even with very deep genome coverage, short read lengths cause problems in de novo assemblies. The use of paired-end libraries with a fragment size shorter than twice the read length provides an opportunit...

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Détails bibliographiques
Auteurs principaux: Magoč, Tanja, Salzberg, Steven L.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198573/
https://ncbi.nlm.nih.gov/pubmed/21903629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btr507
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