Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors

Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor c...

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Bibliographic Details
Main Authors: Hamalukic, Melanie, Huelsenbeck, Johannes, Schad, Arno, Wirtz, Stefan, Kaina, Bernd, Fritz, Gerhard
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198428/
https://ncbi.nlm.nih.gov/pubmed/22039482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026413
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