Bcl-x(L) regulates mitochondrial energetics by stabilizing the inner membrane potential

Mammalian Bcl-x(L) protein localizes to the outer mitochondrial membrane, where it inhibits apoptosis by binding Bax and inhibiting Bax-induced outer membrane permeabilization. Contrary to expectation, we found by electron microscopy and biochemical approaches that endogenous Bcl-x(L) also localized...

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Detalhes bibliográficos
Main Authors: Chen, Ying-bei, Aon, Miguel A., Hsu, Yi-Te, Soane, Lucian, Teng, Xinchen, McCaffery, J. Michael, Cheng, Wen-Chih, Qi, Bing, Li, Hongmei, Alavian, Kambiz N., Dayhoff-Brannigan, Margaret, Zou, Shifa, Pineda, Fernando J., O'Rourke, Brian, Ko, Young H., Pedersen, Peter L., Kaczmarek, Leonard K., Jonas, Elizabeth A., Hardwick, J. Marie
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198165/
https://ncbi.nlm.nih.gov/pubmed/21987637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201108059
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