Atonal homolog 1 is required for growth and differentiation effects of Notch/γ-secretase inhibitors on normal and cancerous intestinal epithelial cells

BACKGROUND & AIMS: The Atonal Homolog 1 (Atoh1 or Math1) transcription factor is required for intestinal secretory (goblet, Paneth, enteroendocrine) cell differentiation. Notch/γ-secretase inhibitors (GSIs) block proliferation and induce secretory cell differentiation in the intestine. We used g...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kazanjian, Avedis, Noah, Taeko, Brown, Douglas, Burkart, Jarred, Shroyer, Noah F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197859/
https://ncbi.nlm.nih.gov/pubmed/20621629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.05.081
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