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DNA polymerase accuracy and spontaneous mutation rates: frequencies of purine.purine, purine.pyrimidine, and pyrimidine.pyrimidine mismatches during DNA replication.

DNA from the am16 mutant of bacteriophage phi X174 may be replicated in vitro and expressed in vivo to give five classes of revertants. Each class may be specifically induced by the appropriate biasing of the concentrations of deoxynucleoside triphosphates in a predictable manner. The frequency of e...

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Библиографические подробности
Опубликовано в::Proc Natl Acad Sci U S A
Главные авторы: Fersht, A R, Knill-Jones, J W
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 1981
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Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319767/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6457301/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.7.4251
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