BACE1 inhibitory activity of fungal endophytic extracts from Malaysian medicinal plants

BACKGROUND: BACE1 was found to be the major β-secretase in neurons and its appearance and activity were found to be elevated in the brains of AD patients. Fungal endophytic extracts for BACE1 inhibitory activity and cytotoxicity against PC-12 (a rat pheochromocytoma with neuronal properties) and WRL...

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Hlavní autoři: Harun, Azzeme, James, Richard Muhammad Johari, Lim, Siong Meng, Majeed, Abu Bakar Abdul, Cole, Anthony LJ, Ramasamy, Kalavathy
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197562/
https://ncbi.nlm.nih.gov/pubmed/21943123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6882-11-79
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