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Mechanisms of atrial-selective block of Na(+) channels by ranolazine: II. Insights from a mathematical model
Block of Na(+) channel conductance by ranolazine displays marked atrial selectivity that is an order of magnitude higher that of other class I antiarrhythmic drugs. Here, we present a Markovian model of the Na(+) channel gating, which includes activation-inactivation coupling, aimed at elucidating t...
Tallennettuna:
| Päätekijät: | , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Physiological Society
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3197376/ https://ncbi.nlm.nih.gov/pubmed/21821780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00243.2011 |
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