Mechanisms of atrial-selective block of Na(+) channels by ranolazine: I. Experimental analysis of the use-dependent block

Atrial-selective inhibition of cardiac Na(+) channel current (I(Na)) and I(Na)-dependent parameters has been shown to contribute to the safe and effective management of atrial fibrillation. The present study examined the basis for the atrial-selective actions of ranolazine. Whole cell I(Na) was reco...

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Bibliographische Detailangaben
Hauptverfasser: Zygmunt, Andrew C., Nesterenko, Vladislav V., Rajamani, Sridharan, Hu, Dan, Barajas-Martinez, Hector, Belardinelli, Luiz, Antzelevitch, Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2011
Schlagworte:
Cardiac Excitation and Contraction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197375/
https://ncbi.nlm.nih.gov/pubmed/21821778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00242.2011
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