Angiotensin II utilizes Janus kinase 2 in hypertension, but not in the physiological control of blood pressure, during low-salt intake

Janus kinase (JAK) 2 is activated by ANG II in vitro and in vivo, and chronic blockade of JAK2 by the JAK2 inhibitor AG-490 has been shown recently to attenuate ANG II hypertension in mice. In this study, AG-490 was infused intravenously in chronically instrumented rats to determine if the blunted h...

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Detalhes bibliográficos
Main Authors: Banes-Berceli, Amy K. L., Al-Azawi, Hind, Proctor, Daniel, Qu, Harvey, Femminineo, Dominic, Hill-Pyror, Crystal, Clinton Webb, R., Brands, Michael W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197339/
https://ncbi.nlm.nih.gov/pubmed/21813872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00071.2011
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