TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway

The biological response to tumor necrosis factor (TNF) involves activation of MAP kinases. Here we report a mechanism of MAP kinase activation by TNF that is mediated by the Rho GTPase family members Rac/Cdc42. This signaling pathway requires Src-dependent activation of the guanosine nucleotide exch...

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Detalhes bibliográficos
Main Authors: Kant, Shashi, Swat, Wojciech, Zhang, Sheng, Zhang, Zhong-Yin, Neel, Benjamin G., Flavell, Richard A., Davis, Roger J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197205/
https://ncbi.nlm.nih.gov/pubmed/21979919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.17224711
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