VALIDATION OF A GENE EXPRESSION-BASED SUBCLASSIFICATION STRATEGY FOR PEDIATRIC SEPTIC SHOCK

OBJECTIVE: Septic shock heterogeneity has important implications for clinical trial implementation and patient management. We previously addressed this heterogeneity by identifying 3 putative subclasses of children with septic shock based exclusively on a 100-gene expression signature. Here we attem...

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Main Authors: Wong, Hector R., Cvijanovich, Natalie Z., Allen, Geoffrey L., Thomas, Neal J., Freishtat, Robert J., Anas, Nick, Meyer, Keith, Checchia, Paul A., Lin, Richard, Shanley, Thomas P., Bigham, Michael T., Wheeler, Derek S., Doughty, Lesley A., Tegtmeyer, Ken, Poynter, Sue E., Kaplan, Jennifer M., Chima, Ranjit S., Stalets, Erika, Basu, Rajit K., Varisco, Brian M., Barr, Frederick E.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196776/
https://ncbi.nlm.nih.gov/pubmed/21705885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e3182257675
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