Chk2-mediated G2/M Cell Cycle Arrest Maintains Radiation Resistance in Malignant Meningioma Cells

In continuation to our studies on radioresistance in meningioma, here we show that radiation treatment (7Gy) induces G2/M cell cycle arrest in meningioma cells. Phosphorylation of Chk2, Cdc25c and Cdc2 were found to be key events since interference with Chk2 activation and cyclin B1/Cdc2 interaction...

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Bibliografiske detaljer
Main Authors: Gogineni, Venkateswara Rao, Nalla, Arun Kumar, Gupta, Reshu, Dinh, Dzung H., Klopfenstein, Jeffrey D., Rao, Jasti S.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196767/
https://ncbi.nlm.nih.gov/pubmed/21945852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.08.022
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