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Encephalopathy in acute liver failure resulting from acetaminophen intoxication: New observations with potential therapy

OBJECTIVE: Hyperammonemia is a major contributing factor to the encephalopathy associated with liver disease. It is now generally accepted that hyperammonemia leads to toxic levels of glutamine in astrocytes. However, the mechanism by which excessive glutamine is toxic to astrocytes is controversial...

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Detalhes bibliográficos
Main Authors: Brusilow, Saul W, Cooper, Arthur J.L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196740/
https://ncbi.nlm.nih.gov/pubmed/21705899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e31822572fd
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