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Topological Structure of the Space of Phenotypes: The Case of RNA Neutral Networks

The evolution and adaptation of molecular populations is constrained by the diversity accessible through mutational processes. RNA is a paradigmatic example of biopolymer where genotype (sequence) and phenotype (approximated by the secondary structure fold) are identified in a single molecule. The e...

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Bibliographic Details
Main Authors: Aguirre, Jacobo, Buldú, Javier M., Stich, Michael, Manrubia, Susanna C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196570/
https://ncbi.nlm.nih.gov/pubmed/22028856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026324
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