Targeted Gene-Silencing Reveals the Functional Significance of Myocardin Signaling in the Failing Heart

BACKGROUND: Myocardin (MYOCD), a potent transcriptional coactivator of smooth muscle (SM) and cardiac genes, is upregulated in failing myocardium in animal models and human end-stage heart failure (HF). However, the molecular and functional consequences of myocd upregulation in HF are still unclear....

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Hlavní autoři: Torrado, Mario, Iglesias, Raquel, Centeno, Alberto, López, Eduardo, Mikhailov, Alexander T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196561/
https://ncbi.nlm.nih.gov/pubmed/22028870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026392
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