The Number of Patients and Events Required to Limit the Risk of Overestimation of Intervention Effects in Meta-Analysis—A Simulation Study

BACKGROUND: Meta-analyses including a limited number of patients and events are prone to yield overestimated intervention effect estimates. While many assume bias is the cause of overestimation, theoretical considerations suggest that random error may be an equal or more frequent cause. The independ...

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Autors principals: Thorlund, Kristian, Imberger, Georgina, Walsh, Michael, Chu, Rong, Gluud, Christian, Wetterslev, Jørn, Guyatt, Gordon, Devereaux, Philip J., Thabane, Lehana
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196500/
https://ncbi.nlm.nih.gov/pubmed/22028777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025491
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