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Mechanisms Controlling Virulence Thresholds of Mixed Viral Populations

The propensity of RNA viruses to revert attenuating mutations contributes to disease and complicates vaccine development. Despite the presence of virulent revertant viruses in some live-attenuated vaccines, disease from vaccination is rare. This suggests that in mixed viral populations, attenuated v...

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Detalhes bibliográficos
Main Authors: Lancaster, Karen Z., Pfeiffer, Julie K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196390/
https://ncbi.nlm.nih.gov/pubmed/21795346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00355-11
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