Asialoglycoprotein receptor mediates the toxic effects of an asialofetuin-diphtheria toxin fragment A conjugate on cultured rat hepatocytes.

We have constructed a toxic hybrid protein that is recognized by asialoglycoprotein (ASGP) receptors of cultured rat hepatocytes. The conjugate consists of fragment A of diphtheria toxin (DTA) linked by a disulfide bond to asialofetuin (ASF). This conjugate is highly toxic, inhibiting protein synthe...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Cawley, D B, Simpson, D L, Herschman, H R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1981
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319572/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6167984/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.6.3383
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