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Hydrogen bonding, overlap geometry, and sequence specificity in anthracycline antitumor antibiotic.DNA complexes in solution.

We have deduced structural aspects of the intercalation complex of the anthracycline antitumor antibiotic daunomycin and its analogs with the synthetic DNA poly(dA-dT) by 1H and 31P NMR in high-salt solution. We demonstrate that the base pairs are intact at the antibiotic binding site and that the a...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Patel, D J, Kozlowski, S A, Rice, J A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319562/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6267584/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.6.3333
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