Mice overexpressing BAFF develop a commensal flora–dependent, IgA-associated nephropathy

B cell activation factor of the TNF family (BAFF) is a potent B cell survival factor. BAFF overexpressing transgenic mice (BAFF-Tg mice) exhibit features of autoimmune disease, including B cell hyperplasia and hypergammaglobulinemia, and develop fatal nephritis with age. However, basal serum IgA lev...

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Detalhes bibliográficos
Main Authors: McCarthy, Douglas D., Kujawa, Julie, Wilson, Cheryl, Papandile, Adrian, Poreci, Urjana, Porfilio, Elisa A., Ward, Lesley, Lawson, Melissa A.E., Macpherson, Andrew J., McCoy, Kathy D., Pei, York, Novak, Lea, Lee, Jeannette Y., Julian, Bruce A., Novak, Jan, Ranger, Ann, Gommerman, Jennifer L., Browning, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195458/
https://ncbi.nlm.nih.gov/pubmed/21881212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45563
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